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Topoisomerase 2 alpha

WebAnti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast … DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands … See more TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. See more In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate with cell proliferation - but β did not. See more • Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681 See more • Topoisomerase II • TOP2B - Topoisomerase II beta • Gene duplication • Ataxia-telangiectasia See more

Topoisomerase IIα is essential for maintenance of mitotic ... - PNAS

WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small … WebMar 19, 2024 · Here, we investigated the role of topoisomerase IIA (Top2α, an enzyme that is essential in resolving entangled DNA strands during replication) in telomeric DNA … buffer\u0027s x2 https://preferredpainc.net

TOP2A - Wikipedia

WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were … WebOct 13, 2024 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein on luminal breast cancer and its utility as an independent prognostic marker. Immunohistochemical expression of Top 2 A in breast … WebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II-alpha index <1) to high (topo II-alpha index = 86). Amplification of c-erbB-2 was observed in 4 of 28 cases (14%) but did not correlate with high topo II-alpha indices. buffer\u0027s x4

Expression of Topoisomerase II-α in Triple Negative Breast Cancer

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Topoisomerase 2 alpha

7153 - Gene ResultTOP2A DNA topoisomerase II alpha

WebJun 15, 2012 · To better understand how these enzymes act in both contexts, we determined the 2.9-Å-resolution structure of the DNA … WebTopoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin …

Topoisomerase 2 alpha

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WebMay 5, 2014 · cancer agent to target human DNA topoisomerase 2-alpha. Lalit Mohan Nainwal 1, Pratap Parida 2, Aparoo p Das 1 and ParthaSarathi Bairy 1. 1 Department of Pharmaceutical Sciences, ... WebMay 4, 2001 · Subunit. Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. ...

WebControl of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. ... WebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been extensively studied in breast cancer patients treated with anthracyclines. However, results are not conclusive. In this paper, we review some of the published studies addressing ...

WebMay 22, 2013 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein ...

WebAbstract. Topoisomerase II is a key target for several anti-cancer drugs used for breast cancer therapy, including doxorubicin, epirubicin and mitoxantrone. Two isoforms of topoisomerase II (alpha and beta) have been described in human cells which differ in their subcellular localisation, biochemical properties and susceptibility to inhibition ...

WebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of … crockett museum of art sacramentoWebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been … buffer\\u0027s x4WebThe chromosome scaffold is a structural and organizational component of mitotic chromosomes. It comprises proteins that occupy the chromatid core and display a … crockett myers \\u0026 associatesWebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II … buffer\\u0027s x6WebHuman Topoisomerase II Alpha Assay Conditions and Performance QC. Decatenation assays are carried out using kinetoplast DNA substrate in a final volume of 20-30 µl in topo II reaction buffer (50 mM Tris-Cl, pH 8.0, 120 mM KCl, 10 mM MgCl2. 0.5 mM ATP, 0.5 mM dithiothreitol) with 0.2 µg KDNA. Reactions are terminated with 5 µl (per 20 µl ... buffer\u0027s x6WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ... buffer\u0027s x7WebDoussis-Anagnostopoulou IA, Vassilakopoulos TP, Thymara I, et al. Topoisomerase II alpha expression as an independent prognostic factor in Hodgkin’s lymphoma. Clin Cancer Res. … crockett music