The pregnane x receptor

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August undefined, 2024

WebbThe pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands ( Kretschmer and Baldwin, 2005 ). … WebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly …

Nutritional calcium modulates colonic expression of vitamin D receptor …

Webb18 apr. 2016 · The nuclear xenobiotic pregnane X receptor (PXR) is well established as a transcriptional regulator of phase I and phase II drug-metabolizing enzymes and drug … Webb21 jan. 2024 · 孕烷X受体. 孕烷X受体(pregnane X receptor,PXR)是核受体超家族成员之一。其主要功能是感知外来有毒物质的存在，并相应地上调参与解毒和清除这些物质的蛋白 … graffis report

Pregnane X Receptor (PXR): Adrenal, Ketosis & Side Effects

WebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 … Webb10 jan. 2014 · Financial & competing interests disclosure. The authors wish to thank the British Heart Foundation (BS/02/002), the Wellcome Trust (074361/Z/04/Z) and Barts … Webb1 aug. 2004 · P-Glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) constitute a physiologic barrier in the intestine for many of the same substrates. Their expression … graff investigative training

The pregnane x receptor

Receptor X de pregnano - Wikipedia, la enciclopedia libre

Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to …

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Webb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … WebbBackground: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme …

WebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, …

http://www.chinjmap.com/ch/reader/create_pdf.aspx?file_no=231339&flag=1&journal_id=zgyx&year_id=2013 WebbThe Pregnane X Receptor. Pregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating …

Webb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. …

Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory … graffinware army baseWebb1 apr. 2024 · It is well-known that the pregnane X receptor (PXR)/Nr1i2 is a critical xenobiotic-sensing nuclear receptor enriched in liver and intestine and is responsible for … graffis studio s.r.ohttp://www.paper.edu.cn/scholar/showpdf/MUT2QNyIMTD0YxeQh graffi scratch removerWebb13 juni 2000 · We and others recently described a new member of the steroid/thyroid hormone receptor family, termed the pregnane X receptor (PXR), that serves as a key … graff io artsWebb15 okt. 2024 · Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is … graff ionWebbThe pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma; Cellular Differentiation of … china biggest exportWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad china biggest export country