Webb21 mars 2024 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and …WebbIn addition, STAT3 (and not STAT1 or STAT2) was also crucial in IFN-β-induced IL-10 secretion, since STAT3 knockdown reverse IFN-β effects both in presence and absence of LPS (Figure 3C).In the case of MCP-1 and IP-10 secretion increased by IFN-β, it was observed that only STAT1 was necessary for such effect (Figures 3D,E).In contrast, …
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Webb1 mars 2008 · Indeed, we next demonstrated that Stat1-/- mice that were reconstituted with wild-type bone marrow were still susceptible to infection with Sendai virus, whereas wild-type mice that received Stat1-/- bone marrow retained resistance to infection. The susceptible epithelial Stat1-/- chimeric mice also exhibited increased viral replication as …WebbFor example, PIAS1 and PIAS3 inhibit transcriptional activation by STAT1 and STAT3, respectively by binding and blocking access to the DNA sequences they recognize. The Interferon JAK-STAT Pathway Type I …books about columbus indiana
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WebbInflammation participates importantly in host defenses against infectious agents and injury, but it also contributes to the pathophysiology of atherosclerosis. ... Consequently, STAT1 has been identified as a point of convergence for the cross-talk between the pro-atherogenic IFN-γ, ...Webb24 sep. 2024 · Along with previous studies of STAT1 in ER + breast cancer, we see the impact of STAT1 on ER binding that potentially dictates the breast cancer progression and treatment resistance reported. Thus, ER-STAT1 axis under the low E2 conditions could be a target to help improve the efficacy of the current anti-endocrine treatment modalities …Webb14 apr. 2024 · Background A mechanistic understanding of uncommon immune outcomes such as resistance to infection has led to the development of novel therapies. Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associated with resistance to Mycobacterium tuberculosis (Mtb) infection defined as …goebbert\u0027s pumpkin farm barrington