High theophylline levels

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August undefined, 2024

WebOct 4, 2024 · In patients with theophylline overdose who are at high risk for theophylline-induced seizures, e.g., patients with acute overdoses and serum theophylline concentrations > 100 mcg/mL or chronic overdosage in patients > 60 years of age with serum theophylline concentrations > 30 mcg/mL, the need for anticonvulsant therapy should be anticipated ... WebSep 21, 2024 · If administering aminophylline, the dose should increase by 25% (as aminophylline is 79% to 86% theophylline). Dose calculations …

Theophylline - Gloucestershire Hospitals NHS Foundation Trust

WebIn most individuals, a plasma-theophylline concentration of 10–20 mg/litre (55–110 micromol/litre) is required for satisfactory bronchodilation, although a lower plasma … WebSafe levels for people taking theophylline are often 8 to 20 mcg/mL. Levels above 20 mcg/mL may be harmful and can happen if people take too many pills within a short time … dan houston ceo principal

Chronic obstructive pulmonary disease: Theophylline

WebTheophylline levels may be modestly altered in thyroid dysfunction. In hyperthyroidism, theophylline metabolism is increased, and therefore the dose may need to be reduced as thyroid levels are corrected. Conversely, patients with hypothyroidism may need the dose of theophylline increased as treatment with levothyroxine or liothyronine continues. WebB. Estimate Mr B’s theophylline level at the time of fitting C. How long after stopping Nuelin will Mr B’s theophylline be within the therapeutic range? [Population data: clearance = 0.04 L/hr/kg & volume of distribution = 0.48 L/kg. CHF reduces theophylline clearance by 50%. F … WebJul 26, 2024 · Too high: 20 to 25 µg/mL: Decrease doses by about 10% and recheck serum level after 3 days. 25 to 30 pg/mL: ... Serum levels should be monitored periodically to determine the theophylline level associated with observed clinical response and to identify the potential for toxicity. For such measurements, the serum sample should be obtained … dan howcroft

theophylline - General Practice notebook

Theophylline Side Effects: Common, Severe, Long Term - Drugs.com

WebNo food or liquid (other than water) was allowed for 4 hours after which a standard lunch was served. Mean peak theophylline serum levels (C max) was 6.69 mcg/mL and mean time of peak serum concentration (T ... In patients with high theophylline clearance and half-lives of about 4 to 5 hours, such as children age 1 to 9 years, the trough serum ... dan howard wilson obituaryWebTherapeutic levels: 4 to 12 mcg/ml [SI: 17 to 51 micromole/L] Note: 4 to 8 mcg/mL if patient is receiving other anticonvulsants. Half-life: 8 - 60 hours in adults Epoxide metabolite: 25 to 43 hours (active metabolite) Time to … birt city of philadelphia

"WebSixty patients with theophylline toxicity were hospitalized during a 2-year period. Eleven patients had hypercalcemia; their calcium levels returned to normal as theophylline levels … " - High theophylline levels

High theophylline levels

Theophylline FAQs Frequently Asked Questions - National Jewish …

WebAug 31, 2024 · High-risk cases include the following: Acute overdose with theophylline levels higher than 80 mcg/mL Chronic toxicity with levels higher than 40 mcg/mL Patients … WebMar 1, 2024 · At serum Theophylline concentrations > 20 mcg/mL, both the frequency and severity of adverse reactions increase. In general, maintaining peak serum Theophylline concentrations between 10 mcg/mL and 15 …

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WebFeb 26, 2013 · Theophylline increases histone deacetylase-2 (HDAC2) via inhibition of phosphoinositide-3-kinase-δ (PI3Kδ), which is activated by oxidative stress to phosphorylate and reduce HDAC2. HDAC2 deacetylates core histones that have been acetylated by the histone acetyltransferase (HAT) activity of coactivators, such as CREB-binding protein … WebSerum theophylline levels were measured in 23 consecutive asthmatics presenting to the ER in an acute attack. 15 (68%) had therapeutic levels (above 10 mcg/ml) and 2 had toxic levels (above 20 mcg/ml), prior to receiving the standard …

WebMar 22, 2024 · Theophylline: Although causality has not been established, concurrent use of pentoxifylline with theophylline has resulted in elevated theophylline plasma levels, which may enhance the possibility of adverse effects. Drug-Food Interactions. Interactions with food have not been established. Drug-Herb Interactions WebThe adverse effects of theophylline include: Gastrointestinal disorders such as nausea, vomiting, gastro-oesophageal reflux. Neurological disorders such as tremor, headache, dizziness, central nervous system stimulation, insomnia, and convulsion (rare). Psychiatric disorders such as anxiety.

WebJul 22, 2024 · The molecular formula of anhydrous theophylline is C 7 H 8 N 4 O 2 with a molecular weight of 180.17. Theo-24 is available as capsules intended for oral administration, containing 100 mg, 200 mg, 300 mg, or 400 mg of anhydrous theophylline per capsule, in an extended-release formulation which allows a 24-hour dosing interval for … WebMany factors affect the rate of theophylline metabolism. Concentrations are increased in heart failure, cirrhosis, viral infections and in the elderly, and decreased in smokers, …

WebAug 31, 2024 · high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor. Serious side effects may be more likely in older adults. Common side effects …

WebFactor which increase the half life include heart failure, cirrhosis, viral infection and drugs like cimetidine, ciprofloxacin, erythromycin and the oral contraceptive pill. The half life is decreased by smoking, heavy drinking and drugs like phenytoin, carbamazepine, rifampicin and barbiturates. birtchwood wooden productsWebFeb 10, 2024 · The reference therapeutic ranges of theophylline are listed below. Reference ranges of theophylline in the treatment asthma vary by age, as follows: Adults: 5-15 µg/mL. Children: 5-10 µg/mL. The... The assessment and diagnosis of exercise-induced bronchoconstriction is made … dan howard maternity swimsuitWebNov 3, 2024 · Haemodialysis (if possible charcoal haemoperfusion is the modality of choice). Indications for dialysis include: Theophylline level … dan housley channel 7WebJan 14, 2024 · Check with your doctor immediately if any of the following side effects occur while taking theophylline: Incidence not known Chest pain or discomfort dizziness fainting fast, slow, or irregular heartbeat increase in urine volume lightheadedness persistent vomiting pounding or rapid pulse seizures shakiness birtchwood ak car repairWebSymptoms usually manifest if serum theophylline level 20-25 mg/L 1, 2. Symptoms increase in frequency and severity with increasing levels (significant individual variability exists … birtch place co-operative homesWebAnswer: A theophylline level is a measure of theophylline in the bloodstream. This is used to regulate the dose. A blood level between 5-15 µg/ml often gives good relief of symptoms … birt conditional formattingWebJun 20, 2024 · High blood sugar (increased thirst, increased urination, hunger, dry mouth, drowsiness, blurred vision, weight loss) ... Low levels of theophylline and caffeine may indicate that the drug has not reached a therapeutic level for the individual tested and there is insufficient drug present to be effective. danhowell.com