Ctgf migration

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August undefined, 2024

WebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... In addition to fibrosis, CTGF has multiple functions, including cell adhesion and migration. CTGF expression is upregulated in ... WebFeb 6, 2024 · The migration assays showed that GFs with CM from CAFs strongly enhanced GIST-T1 cell migration compared to GF only, while the effect was markedly decreased by anti-TGF-β1 blocking antibody (Fig ...

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WebFeb 21, 2024 · Connective tissue growth factor (CTGF), identified as an endochondral ossification genetic factor, plays a vital role in cell proliferation, migration and adhesion. However, how CTGF regulates GJIC in chondrocytes is still unknown. This study aims to explore the effects of CTGF on GJIC in chondrocytes and its potential biomechanism. WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … how is hinduism unique

Connective tissue growth factor decreases mitochondrial …

WebJun 6, 2012 · These tumors demonstrate several phenotypes potentially related to CTGF function namely: cell migration, absent tumor cell apoptosis, as well as, reactive and well vascularised myofibroblast rich stroma and fibrosis development locally and in distal organs. ... Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the ... WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such … WebMar 10, 2024 · The protein expression and mRNA levels of the profibrotic cytokines (VEGF and CTGF), migration and adhesion-associated molecules (VCAM-1 and ICAM-1), and ECM-associated molecules (MMP2 and TIMP-1) were elevated in the model group. After LN treatment, they were all significantly downregulated in the LN group (Figures 11(e)–11(k)). how is hinduism different from other faiths

Effects and Regulation of Connective Tissue Growth Factor on …

The protein-protein interaction between connective tissue growth …

WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebCTGF can decrease glycolysis, mitochondrial oxidative phosphorylation, ATP generation, and mtDNA copy number by increasing mtTFA protein degradation through ubiquitin proteasome pathway and in turn reduces migration and invasion of OSCC cells. Therefore, CTGF may be developed as a potential additive … how is hindu new year celebratedWebAs shown in Fig. 5, the number of Panc-1 cells that invaded through the matrigel chamber was signi fi cantly less in the group transfected with MUC1 siRNA than that observed in control groups (P b ... highland modern dentistry

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Ctgf migration

CTGF Loaded Electrospun Dual Porous Core-Shell Membrane For …

WebFeb 13, 2024 · 3.3. CAP Accelerates Migration through the Activation of the YAP-CTGF-Cyr61 Axis. Quantitative real-time PCR revealed that CAP significantly stimulated YAP mRNA expression at 6 hr in GM Fbs (Figure 3(b)).CAP also tends to increase YAP at late time points in GM Fbs (18 hr) and HaCaTs (at 24 hr) (Figures 3(a) and 3(b)), and CAP … WebDec 12, 2024 · Angiogenesis is the main basis of the proliferative phase of wound healing, cell proliferation, migration, and differentiation. The integrity of the endothelial cell structure plays a very important role in maintaining normal blood circulation in the body. ... Connective tissue growth factor (CTGF) is a matricellular protein from the …

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WebMar 3, 2004 · Connective tissue growth factor (CTGF, also known as CCN2) is a member of the CCN family, which includes CTGF, cysteine-rich 61 (Cyr61, ... (20– 22); endothelial cell proliferation and migration (23, 24); and regulation of apoptosis in human breast cancer cells and aortic smooth muscle cells (25, 26). WebJul 1, 2024 · Intriguingly, the effect of CTGF on cell migration can either be positive or negative in a cell-type-specific manner [23,24]. The differential actions of CTGF may be attributed to different interacting partners in the extracellular domain . ... Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells ...

WebOct 6, 2024 · Apart from inhibiting TNBC cell migration via CTGF, ATL-1 downregulated the expression of CTGF in fibroblasts and decreased the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblasts (CAFs), which in turn increased the sensitivity of TNBC cells to paclitaxel. In a mouse model, we found that ATL-1 treatments ... WebJan 31, 2024 · Recent studies have identified cell-derived connective tissue growth factor (CTGF) as a novel therapeutic target for the treatment of multiple human diseases, including various types of cancers [6 ...

WebCTGF can regulate the activity of diverse growth factors or integrins. 19,20 CTGF was found to activate the cellular proliferation, migration, and fibrogenesis. 21 CTGF has also been proven to participate in certain types of cancers of drug-resistance. WebNov 4, 2016 · CTGF is a matricellular, multifunctional protein that can influence the activity of multiple major signaling pathways, affecting cell adhesion, migration, proliferation, and differentiation. CTGF expression increases after central nervous system (CNS) trauma in rodents, but its function after spinal cord injury has not been elucidated ( 7 – 9 ).

WebApr 13, 2024 · HIGHLIGHTS who: Samuele Negro from the Eight to ten week-old , mice were employed for laser capture microdissection (LCM) and transcriptional profiling, and for electrophysiological recordingsC BL/, mice expressing cytosolic … Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth …

WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that … how is hinduism todayWebApr 12, 2024 · Corning 3422 inserts were used to evaluate the cell migration capacity. HLF and Hep3B cells were transfected with siUSP1 or siControl. ... The expression of CTGF, the most classical Hippo target ... highland modified footballWebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that … highland mobile homes baton rougeWebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, … highland mobile radioWebJun 1, 2002 · Connective tissue growth factor (CTGF) is a 38-kd protein, originally isolated from supernatants of human vascular endothelial cells, that promotes differentiation, proliferation, and migration of ... how is hinge for datingWebJan 27, 2024 · A novel integrin α5β1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 55 , 856–862 (2006). how is hint water madeWebOct 26, 2024 · Connective tissue growth factor (CTGF), also known as CCN family protein 2 (CCN2), is composed of four domains, including insulin-like growth factor binding … how is hipaa important